Adami G F, Leandri R, Sarles J C
Gastroenterol Clin Biol. 1986 Feb;10(2):108-11.
The action of somatostatin on the myoelectrical activity of the sphincter of Oddi was studied in anesthetized rabbits equipped with bipolar electrodes. The activity of the sphincter was recorded at the basal state and during 30 min after injection of somatostatin. After a bolus injection of somatostatin (1 to 8 micrograms/kg), the myoelectrical activity of the sphincter of Oddi decreased between the 2nd and the 10th min with a parallel decrease of the biliary pressure. These modifications were significant at the doses of 4 and 8 micrograms/kg only. There was a good dose-effect relationship. Moreover, the infusion of somatostatin (60 micrograms/kg/h) led to a decrease in sphincter activity. Bolus injection of cholecystokinin (2 UD/kg) under somatostatin infusion (60 micrograms/kg/h) induced an increase in the activity of the sphincter of Oddi. However, this activity never returned to basal levels.
在配备双极电极的麻醉兔身上，研究了生长抑素对Oddi括约肌肌电活动的作用。在基础状态以及注射生长抑素后30分钟内记录括约肌的活动。静脉推注生长抑素（1至8微克/千克）后，Oddi括约肌的肌电活动在第2至10分钟之间降低，同时胆管压力也平行下降。仅在4和8微克/千克的剂量下，这些变化具有显著性。存在良好的剂量效应关系。此外，输注生长抑素（60微克/千克/小时）导致括约肌活动降低。在输注生长抑素（60微克/千克/小时）的情况下静脉推注胆囊收缩素（2单位/千克）可诱导Oddi括约肌活动增加。然而，这种活动从未恢复到基础水平。
