蒽环类抗生素的微生物转化。I. 阿克拉霉素B向阿克拉霉素A的微生物转化。
Microbial conversion of anthracycline antibiotics. I. Microbial conversion of aclacinomycin B to aclacinomycin A.
作者信息
Hoshino T, Sekine Y, Fujiwara A
出版信息
J Antibiot (Tokyo). 1983 Nov;36(11):1458-62. doi: 10.7164/antibiotics.36.1458.
PMID:6581152
Abstract
Streptomyces galilaeus OBB-111 and its blocked mutant were found to convert aclacinomycin B and related anthracycline glycosides of the B type to the corresponding A-type glycosides. Only the cell fraction of cultures of S. galilaeus OBB-111 was capable of catalyzing the reaction. The activity was associated with growth but disappeared before the start of rapid production of aclacinomycins A and B.
摘要
发现加利利链霉菌OBB - 111及其阻断突变体可将阿克拉霉素B及相关B型蒽环类糖苷转化为相应的A型糖苷。只有加利利链霉菌OBB - 111培养物的细胞部分能够催化该反应。该活性与生长相关，但在阿克拉霉素A和B快速产生开始之前就消失了。
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