存在一种内源性因子干扰3H-地西泮与大鼠脑膜结合的证据。
Evidence for an endogenous factor interfering with 3H-diazepam binding to rat brain membranes.
作者信息
Karobath M, Sperk G, Schönbeck G
出版信息
Eur J Pharmacol. 1978 Jun 1;49(3):323-6. doi: 10.1016/0014-2999(78)90111-5.
PMID:658148
Abstract
An in vitro "receptor" binding assay has been used to search for an endogenous compound which possibly interacts with benzodiazepine receptors in brain. Such an endogenous 3H-diazepam binding inhibitory factor (DIF) has been found. This compound is unevenly distributed in brain and in various peripheral organs. The partially purified compound appears to have a low molecular weight (below 500) and is not inactivated by proteolytic enzymes.
摘要
一种体外“受体”结合试验已被用于寻找一种可能与脑中苯二氮䓬受体相互作用的内源性化合物。现已发现这样一种内源性的3H-地西泮结合抑制因子（DIF）。这种化合物在脑和各种外周器官中的分布不均匀。部分纯化的化合物似乎具有低分子量（低于500），并且不会被蛋白水解酶灭活。
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