Christensen C M, Navazesh M, Brightman V J
Arch Oral Biol. 1984;29(1):17-23. doi: 10.1016/0003-9969(84)90037-2.
The effects of short-term salivary flow reductions on human taste thresholds were measured. Recognition and detection thresholds were obtained from 65 subjects during periods of both normal and reduced salivary flow. Decreased salivary flow was achieved by oral administration of either Elavil, Benadryl or atropine. Thresholds were measured for NaCl, citric acid, quinine sulphate and sucrose with a traditional series of aqueous solutions as well as with a series of dry taste stimuli using a filter-paper base. Whole mouth resting flow and stimulated salivary flow were measured before and after taste testing. The pharmacologic agents produced depressions in salivary flow ranging between 30 and 75 per cent of normal levels. The large decreases in flow produced no measurable changes in taste thresholds with the exception that an increased sensitivity to aqueous and dry citric acid stimuli consistently was observed following atropine administration. Changes in salivary bicarbonate levels, produced by atropine, may have mediated the observed shifts in oral sensitivity to citric acid.
测量了短期唾液分泌减少对人类味觉阈值的影响。在唾液分泌正常和减少的时期，从65名受试者中获得识别阈值和检测阈值。通过口服阿密替林、苯海拉明或阿托品来减少唾液分泌。使用传统的一系列水溶液以及以滤纸为基质的一系列干味刺激物，测量了氯化钠、柠檬酸、硫酸奎宁和蔗糖的阈值。在味觉测试前后测量全口静息流量和刺激唾液流量。这些药物使唾液分泌减少至正常水平的30%至75%。除了在服用阿托品后持续观察到对水性和干柠檬酸刺激的敏感性增加外，唾液分泌的大幅减少并未使味觉阈值发生可测量的变化。阿托品引起的唾液碳酸氢盐水平变化可能介导了观察到的口腔对柠檬酸敏感性的变化。
