Brotman A W, Herzog D B, Woods S W
J Clin Psychiatry. 1984 Jan;45(1):7-9.
In a retrospective study, 22 patients with bulimia were treated with at least one therapeutic trial of antidepressants. Most patients (77%) were clinically depressed before the drug trial. Bingeing frequency decreased in 59% of all cases, and depression improved in 58% of depressed subjects after a 4-week trial of antidepressants, although only 27% of all patients showed both an antibinge and an antidepressant response. Furthermore, during a 3-month follow-up period, several patients relapsed despite continuing medication. At the end of the follow-up period, 23% of subjects continued to show at least a 50% decrease in their bingeing. These data indicate that medication may have separate and possibly unrelated antibinge and antidepressant effects in this patient population.
在一项回顾性研究中，22名贪食症患者接受了至少一次抗抑郁药治疗试验。大多数患者（77%）在药物试验前临床抑郁。在所有病例中，59%的患者暴饮暴食频率降低，在进行为期4周的抗抑郁药试验后，58%的抑郁患者抑郁症状有所改善，尽管所有患者中只有27%同时出现了抗暴饮暴食和抗抑郁反应。此外，在3个月的随访期内，尽管持续用药，仍有几名患者复发。在随访期结束时，23%的受试者暴饮暴食频率至少持续降低了50%。这些数据表明，在该患者群体中，药物可能具有单独的、可能不相关的抗暴饮暴食和抗抑郁作用。
