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Cocarcinogens of the diterpene ester type from Croton flavens L. and esophageal cancer in Curaçao.

作者信息

Weber J, Hecker E

出版信息

Experientia. 1978 Jun 15;34(6):679-82. doi: 10.1007/BF01947253.

DOI:10.1007/BF01947253
PMID:658270
Abstract

From the roots of Croton flavens L., 3 highly irritant and tumor promoting Croton factors F1--F3 and the corresponding 3 cryptic Croton factors F'1--F'3 were isolated and characterized as novel esters of 16-hydroxy- and 4-deoxy-16-hydroxyphorbol, respectively. These findings suggest that tumor promoters of the phorbol ester type, ingested through the widespread and frequent use of Croton flavens according to local habits, may be causally related to the well recognized high rate of esophageal cancer on Curaçao.

摘要

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本文引用的文献

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Plants associated with esophageal cancer cases in Curacao.库拉索岛食管癌病例相关的植物。
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[On the biologically active compounds of euphorbiaceae. I. Skinirritant and cocarcinogenic factors from Euphorbia cooperi N.E.Br (author's transl)].[关于大戟科植物的生物活性化合物。I. 库珀大戟（Euphorbia cooperi N.E.Br）中的皮肤刺激和促癌因素（作者译）]
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