A new antisickling agent: in vitro studies of its effect on S/S erythrocytes and on hemoglobin S.

Adhikary P K, Haynes J K, Patthey H L, Rhodes R S

Experientia. 1978 Jun 15;34(6):804-6. doi: 10.1007/BF01947338.

2-(benzoylamino) pyridinium benzoate (BAPB) has exhibited an antisickling effect with homozygous S/S erythrocytes in vitro. This study suggests that BAPB prevents sickling by inhibiting the gelation of hemoglobin S.