Takazoe I, Nakamura T, Okuda K
J Dent Res. 1984 Mar;63(3):422-6. doi: 10.1177/00220345840630031201.
The initial event in colonization of the subgingival area by B. gingivalis is its attachment to host cells and Gram-positive bacteria in pre-formed plaque. The level of B. gingivalis is partly governed by products of other plaque bacteria, especially by sanguicin. Once B. gingivalis resides in its nidus and starts to proliferate, expulsion of pre-existing residents may occur, especially of attached Gram-positive bacteria, through the inhibitory action of the B. gingivalis product, hematin. The bacteriocin produced by black-pigmented Bacteroides also seems to play an important role in their establishment. Melaninogenicus possessed strong inhibitory activity against Actinomyces species. This was not completely confirmed with fresh isolates of B. gingivalis from advanced periodontitis patients. Various factors other than inhibitory substances produced by B. gingivalis and related bacteria can also affect the colonization of this species. Since the crevice area is influenced by gingival fluid, the nature of specific antibody and the other affecting components should be considered collectively with the interaction between new predominant colonizers and other pre-existing residents.
牙龈卟啉单胞菌在龈下区域定植的初始事件是其附着于预先形成的菌斑中的宿主细胞和革兰氏阳性菌。牙龈卟啉单胞菌的水平部分受其他菌斑细菌产物的调控，尤其是血生素。一旦牙龈卟啉单胞菌在其病灶中定居并开始增殖，可能会通过牙龈卟啉单胞菌产物血红素的抑制作用，排挤已有的定居菌，尤其是附着的革兰氏阳性菌。产黑色素拟杆菌产生的细菌素似乎在它们的定植中也起重要作用。产黑色素普氏菌对放线菌属具有很强的抑制活性。这一点在晚期牙周炎患者的新鲜牙龈卟啉单胞菌分离株中并未得到完全证实。除牙龈卟啉单胞菌及相关细菌产生的抑制物质外，其他各种因素也会影响该菌的定植。由于裂隙区域受龈沟液影响，因此在考虑新的优势定植菌与其他已定居菌之间相互作用时，应综合考虑特异性抗体的性质及其他影响成分。
