McArthur W P, Magnusson I, Marks R G, Clark W B
Periodontal Disease Research Center, University of Florida, Gainesville 32610.
Infect Immun. 1989 Aug;57(8):2313-7. doi: 10.1128/iai.57.8.2313-2317.1989.
Periodontal diseases are inflammatory responses thought to be triggered by specific microorganisms colonizing in the gingival crevice. Theoretically, periodontal diseases could be prevented if the etiologic organisms were not allowed to colonize the subgingival area. The humoral immune response is one mechanism which may modulate bacterial colonization in the gingival crevice. To test the effect of systemic humoral immunity on subgingival colonization by bacteria, squirrel monkeys (Saimiri sciureus) were immunized with Bacteroides gingivalis, a black-pigmented Bacteroides sp. and putative periodontal pathogen. Immunized and sham-immunized monkeys were orally inoculated with 10(10) viable B. gingivalis during ligation of five teeth in one quadrant with bacterium-soaked suture material and distribution over the entire dentogingival margin. Immunization resulted in an increased level of immunoglobulin G anti-B. gingivalis in serum and was associated with a strong trend toward a statistically significant reduction in colonization of the gingival crevice by black-pigmented bacteroides.
牙周疾病是一种炎症反应，被认为是由在牙龈沟定植的特定微生物引发的。从理论上讲，如果不允许致病生物在龈下区域定植，牙周疾病是可以预防的。体液免疫反应是一种可能调节牙龈沟内细菌定植的机制。为了测试全身体液免疫对细菌在龈下定植的影响，用牙龈拟杆菌（一种产黑色素拟杆菌属菌种及假定的牙周病原体）对松鼠猴（松鼠猴属）进行免疫。在一个象限的五颗牙齿用浸有细菌的缝合材料结扎并分布于整个牙-牙龈边缘时，对免疫和假免疫的猴子经口接种10¹⁰ 活的牙龈拟杆菌。免疫导致血清中抗牙龈拟杆菌免疫球蛋白G水平升高，并与产黑色素拟杆菌在牙龈沟定植的统计学显著减少的强烈趋势相关。
