Pearce R H, Grimmer B J
J Rheumatol Suppl. 1983 Dec;11:108-10.
Seventy-five intervertebral discs from 15 spines were analyzed after morphologic grading. With degeneration, the water and proteoglycan (PG) contents decreased and the collagen content increased. The PG was isolated from 20 discs by single-stage dissociative density gradient ultracentrifugation. Neither the chondroitin 6-sulphate nor the protein contents of the PG changed with degeneration although the keratan sulphate fell slightly.
对15个脊柱的75个椎间盘进行形态学分级后进行分析。随着退变，水分和蛋白聚糖（PG）含量降低，胶原蛋白含量增加。通过单级解离密度梯度超速离心从20个椎间盘中分离出PG。尽管硫酸角质素略有下降，但PG的硫酸软骨素6-硫酸盐和蛋白质含量均未随退变而改变。
