Dong F, Dai K, Hou X
Ninth People's Hospital, Shanghai Second Medical University.
Zhonghua Yi Xue Za Zhi. 1995 Jun;75(6):352-4, 383.
Using a computer based image analysis system and histological sections stained with Safranin O, we investigated systematically the variation of proteoglycans (PG) contents in the low lumbar discs of bipedal rats. Topographically, the PG concentration increased from the outer annulus to the inner nucleus pulposus region, which possesses the highest PG concentration. The PG content decreased with age, and a significant loss of PG was observed in the lumbar discs of bipedal rats as compared with controls, especially in the nucleus pulposus. These observations support the view that the higher abnormal mechanical stress accelerates disc degeneration.
我们使用基于计算机的图像分析系统和用番红O染色的组织学切片，系统地研究了双足大鼠下腰椎间盘蛋白聚糖（PG）含量的变化。从地形学角度来看，PG浓度从外环向具有最高PG浓度的内核髓核区域增加。PG含量随年龄下降，与对照组相比，双足大鼠腰椎间盘尤其是髓核中观察到PG显著流失。这些观察结果支持了更高的异常机械应力会加速椎间盘退变这一观点。
