Hu C P, Hsieh H G, Chien K Y, Wang P Y, Wang C I, Chen C Y, Lo S J, Wuu K D, Chang C M
J Natl Cancer Inst. 1984 Mar;72(3):577-83.
Three epithelial cell lines, CE-48T/VGH, CE-69T/-VGH, and CE-81T/VGH, were established from human squamous cell carcinoma of the esophagus. The cells were polygonal with a high nucleus-to-cytoplasm ratio. Many cells were multinucleate. Electron microscopy revealed the presence of tonofilaments and desmosomes. Chromosome analysis showed that these 3 cell lines were heteroploids of human origin. When transplanted into BALB/c (nu/nu) mice, CE-69T/VGH and CE-81T/VGH produced tumors, the histology of which proved to be carcinomas. All 3 cell lines secreted carcinoembryonic antigen. However, the secretion patterns were different. These 3 cell lines may provide useful models for the study of human esophageal cancer.
三种上皮细胞系，CE - 48T/VGH、CE - 69T/-VGH和CE - 81T/VGH，是从人食管鳞状细胞癌中建立的。细胞呈多边形，核质比高。许多细胞为多核细胞。电子显微镜显示存在张力丝和桥粒。染色体分析表明这三种细胞系是源自人类的异倍体。当移植到BALB/c（nu/nu）小鼠体内时，CE - 69T/VGH和CE - 81T/VGH产生了肿瘤，其组织学证明为癌。所有三种细胞系均分泌癌胚抗原。然而，分泌模式有所不同。这三种细胞系可能为人类食管癌的研究提供有用的模型。
