进化上不同群体中的双重频率。
Doublet frequencies in evolutionary distinct groups.
作者信息
Nussinov R
出版信息
Nucleic Acids Res. 1984 Feb 10;12(3):1749-63. doi: 10.1093/nar/12.3.1749.
Abstract
We analyze the dinucleotide frequencies of occurrence and preferences separately within the vertebrates, nonvertebrates, DNA viruses, mitochondria, RNA viruses, bacteria and phage sequences. Over half a million nucleotides from more than 400 sequences were used in this study. Distinct patterns are observed. Some of the patterns are common to all sequences, some to either eukaryotes or prokaryotes and others to the subgroups within them. Doublets are the most basic ingredient of order in nucleotide sequences. We suggest that their preferences and the arrangement of nucleotides in the DNA in general is determined to a large extent by the conformational and packaging considerations of the double helix. Some principles of DNA conformation are viewed in light of our results.
摘要
我们分别分析了脊椎动物、无脊椎动物、DNA病毒、线粒体、RNA病毒、细菌和噬菌体序列中双核苷酸的出现频率和偏好性。本研究使用了来自400多个序列的超过50万个核苷酸。观察到了不同的模式。其中一些模式在所有序列中都很常见，一些在真核生物或原核生物中常见，还有一些在它们各自的亚组中常见。双联体是核苷酸序列中秩序的最基本组成部分。我们认为，它们的偏好以及DNA中核苷酸的排列在很大程度上是由双螺旋的构象和包装因素决定的。根据我们的结果对DNA构象的一些原则进行了探讨。
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