植物系统中的CpG和TpA频率。
CpG and TpA frequencies in the plant system.
作者信息
Boudraa M, Perrin P
出版信息
Nucleic Acids Res. 1987 Jul 24;15(14):5729-37. doi: 10.1093/nar/15.14.5729.
Abstract
Higher plant nuclear sequences reveal avoidance of CpG and TpA doublets. Chloroplast sequences avoid the TpA doublet in all codon positions. The chloroplast genome is not methylated but codon positions II-III and untranslated regions avoid CpG. The mitochondrial genome, also unmethylated, avoids CpG in all codon positions. We therefore deduce that methylation is not sufficient to explain CpG avoidance in the higher plant systems. Other factors must be taken into account such as amino acid composition, codon choices and perhaps stability of the DNA helix.
摘要
高等植物的核序列显示出对CpG和TpA双联体的回避。叶绿体序列在所有密码子位置都回避TpA双联体。叶绿体基因组不发生甲基化，但密码子的第二和第三位置以及非翻译区回避CpG。线粒体基因组同样不发生甲基化，在所有密码子位置都回避CpG。因此我们推断，甲基化不足以解释高等植物系统中对CpG的回避。必须考虑其他因素，如氨基酸组成、密码子选择以及或许还有DNA螺旋的稳定性。
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