最近邻核苷酸模式。结构和生物学意义。

Nearest neighbor nucleotide patterns. Structural and biological implications.

作者信息

Nussinov R

出版信息

J Biol Chem. 1981 Aug 25;256(16):8458-62.

Abstract

Recently, nearest neighbor patterns were observed in prokaryotic and eukaryotic DNA sequences. These are discussed with respect to some of their biological implications. It is suggested that their origins relate to different specific structures of nearest neighbor base pairs. These patterns strongly constrain the DNA sequence. As such, they "explain" to some degree the amino acid codon choice and have direct bearing on questions related to evolution.

摘要

最近，在原核生物和真核生物的DNA序列中观察到了最近邻模式。本文讨论了它们的一些生物学意义。研究表明，它们的起源与最近邻碱基对的不同特定结构有关。这些模式强烈地限制了DNA序列。因此，它们在一定程度上“解释”了氨基酸密码子的选择，并与进化相关问题直接相关。