[X射线造影剂对大鼠肝微粒体对外源化学物质和类固醇激素代谢的影响]
[Effect of x-ray contrast substances on the metabolism of xenobiotics and steroid hormones by rat liver microsomes].
作者信息
Sergeev P V, Bol'shev V N
出版信息
Farmakol Toksikol. 1978 May-Jun;41(3):331-3.
PMID:658383
Abstract
Uro- and cholecystographic contrast media are shown to be capable of changing the rate of oxidative hydroxylation of amidopyrine and steroid hormones. The degree and duration of the diminishing rate of the xenobiotics and steroids metabolism are determined by concentrations of the X-ray contrast media in hepatic cells and the rate of their clearance.
摘要
尿路造影剂和胆囊造影剂被证明能够改变氨基比林和类固醇激素的氧化羟基化速率。异生物素和类固醇代谢速率降低的程度和持续时间取决于肝细胞中X射线造影剂的浓度及其清除率。
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