通过等电聚焦法鉴定的BfF的两种亚型：与其他HLA标记的差异连锁

Two subtypes of BfF by isoelectrofocusing: differential linkage to other HLA markers.

作者信息

Abbal M, Thomsen M, Cambon-Thomsen A, Archambeau J, Calot M, Fathallah D

出版信息

Hum Genet. 1985;69(2):181-3. doi: 10.1007/BF00293294.

Abstract

By isoelectrofocusing in agarose, the properdin factor allotype BfF could be split into two subtypes: BfFa with one major cathodic band and BfFb with the same cathodic band but in addition a major anodic band. By scanning, BfFaFb heterozygotes were distinguished from BfFbFb homozygotes by the stronger intensity of the anodic band in the latter. The two subtypes were segregated perfectly with HLA in 40 families and showed different association patterns with HLA markers. BfFa seemed to be linked to B35 while BfFb showed a strong linkage with all the components of the following haplotype: HLA-A29, Cw-, B44, BfFb, C4A3B1, DR7. The frequency of BfFa among BfFS heterozygotes was 41% (46/113) and that of BfFb 59% (67/113).

摘要

通过在琼脂糖中进行等电聚焦，备解素因子同种异型BfF可分为两个亚型：BfFa有一条主要的阴极带，BfFb有相同的阴极带，但除此之外还有一条主要的阳极带。通过扫描，BfFaFb杂合子与BfFbFb纯合子的区别在于后者阳极带的强度更强。在40个家族中，这两个亚型与HLA完美分离，并显示出与HLA标记不同的关联模式。BfFa似乎与B35连锁，而BfFb与以下单倍型的所有成分有很强的连锁关系：HLA-A29、Cw-、B44、BfFb、C4A3B1、DR7。BfFS杂合子中BfFa的频率为41%（46/113），BfFb的频率为59%（67/113）。