Iwata N, Karasawa M, Omine M, Maekawa T, Suzuki T, Kawai Y
Cancer Treat Rep. 1984 Mar;68(3):527-9.
A marked prolongation of QTc (corrected QT interval for heart rate) in ECG developed in two patients with acute leukemia during induction chemotherapy with aclarubicin, one of the anthracycline antibiotics. This ECG change was followed by ventricular fibrillation. No signs or symptoms of congestive heart failure were noted. The outcome in one case was fatal; in the other case, the ECG change was reversible. These observations suggest that QTc prolongation, which has been considered to be a sign of acute cardiotoxicity of anthracycline derivatives, may signal a clinical risk of ventricular fibrillation.
两名急性白血病患者在使用阿柔比星（一种蒽环类抗生素）进行诱导化疗期间，心电图出现了明显的QTc（心率校正QT间期）延长。这种心电图变化之后出现了心室颤动。未观察到充血性心力衰竭的体征或症状。一例患者死亡；另一例患者的心电图变化是可逆的。这些观察结果表明，QTc延长一直被认为是蒽环类衍生物急性心脏毒性的一个迹象，可能预示着心室颤动的临床风险。
