蒙特卡罗计算在微管亚基动力学研究中的应用。
Use of Monte Carlo calculations in the study of microtubule subunit kinetics.
作者信息
Chen Y, Hill T L
出版信息
Proc Natl Acad Sci U S A. 1983 Dec;80(24):7520-3. doi: 10.1073/pnas.80.24.7520.
Abstract
GTP-tubulin forms a cap on microtubule ends during aggregation. The bulk of the microtubule is GDP-tubulin. This complicates the usual simple kinetic theory of subunit exchange at microtubule ends to such an extent that Monte Carlo calculations are needed to handle the complications, except in special cases. The Monte Carlo method is introduced here, for this problem, and illustrated with steady-state and transient examples. Monte Carlo transients are needed to simulate dilution experiments. Preliminary results (with M. F. Carlier) have been obtained applying these theoretical procedures to experimental data.
摘要
在微管聚集过程中，GTP - 微管蛋白在微管末端形成帽状结构。微管的主体是GDP - 微管蛋白。这使得微管末端亚基交换的常规简单动力学理论变得极为复杂，以至于除了特殊情况外，需要用蒙特卡罗计算来处理这些复杂情况。本文针对此问题引入了蒙特卡罗方法，并通过稳态和瞬态示例进行说明。模拟稀释实验需要蒙特卡罗瞬态。（与M. F. 卡利尔合作）已将这些理论程序应用于实验数据并获得了初步结果。
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