McConnell S K, LeVay S
Proc Natl Acad Sci U S A. 1984 Mar;81(5):1590-3. doi: 10.1073/pnas.81.5.1590.
In the lateral geniculate nucleus of the mink, on-center and off-center neurons occupy separate layers [LeVay, S. & McConnell, S.K. (1982) Nature (London) 300, 350-351]. To study the mode of termination of geniculate afferents in area 17, we recorded from their terminal arborizations in layer IV after the destruction of cortical neurons by injection of kainic acid. At the majority of recording sites, multifiber responses were entirely or predominantly of one type: on-center or off-center. Responses obtained during perpendicular penetrations showed the same preferred sign of contrast throughout the thickness of layer IV. During tangential penetrations through the layer, we encountered sequences of on- and off-center activity separated by stretches of mixed responses. We conclude that on- and off-center afferents terminate in separate, alternating patches that occupy the full thickness of layer IV. These coexist with another set of patches in which the same afferents are segregated by eye of origin.
在水貂的外侧膝状核中，给光中心和撤光中心神经元占据不同的层[勒维，S. & 麦康奈尔，S.K.（1982年）《自然》（伦敦）300, 350 - 351]。为了研究膝状传入纤维在17区的终止方式，我们在通过注射 kainic 酸破坏皮质神经元后，从它们在IV层的终末分支处进行记录。在大多数记录位点，多纤维反应完全或主要属于一种类型：给光中心或撤光中心。在垂直穿透过程中获得的反应在IV层的整个厚度上显示出相同的偏好对比信号。在通过该层的切向穿透过程中，我们遇到了给光中心和撤光中心活动的序列，其间夹杂着混合反应段。我们得出结论，给光中心和撤光中心传入纤维终止于占据IV层全层的单独、交替的斑块中。这些斑块与另一组斑块共存，在这组斑块中，相同的传入纤维按起源眼进行分离。
