Griffin J D, Ritz J, Beveridge R P, Lipton J M, Daley J F, Schlossman S F
Int J Cell Cloning. 1983 Apr;1(1):33-48. doi: 10.1002/stem.5530010106.
A murine monoclonal antibody (anti-MY7) has been developed that detects an antigen expressed by 6% of normal human bone marrow cells, including approximately 40% of myeloid colony-forming cells (CFU-C). The number of bone marrow cells and CFU-C expressing MY7 is significantly increased in regenerating bone marrow, but less than 5% of peripheral blood CFU-C express the MY7 antigen. Erythroid precursors are MY7 negative from peripheral blood and bone marrow. Thymidine suicide studies indicate that CFU-C in S-phase tend to be MY7 positive while CFU-C not in S-phase are MY7 negative. MY7 expression thus appears to identify a fraction of CFU-C that is actively proliferating.
已研制出一种鼠单克隆抗体（抗-MY7），它能检测出6%的正常人骨髓细胞所表达的一种抗原，其中包括约40%的髓系集落形成细胞（CFU-C）。在再生骨髓中，表达MY7的骨髓细胞和CFU-C数量显著增加，但外周血CFU-C中表达MY7抗原的不到5%。外周血和骨髓中的红系前体细胞为MY7阴性。胸腺嘧啶核苷自杀研究表明，处于S期的CFU-C往往为MY7阳性，而不处于S期的CFU-C为MY7阴性。因此，MY7表达似乎可识别出一部分正在活跃增殖的CFU-C。
