Strauss L C, Brovall C, Fackler M J, Schwartz J F, Shaper J H, Loken M R, Civin C I
Exp Hematol. 1986 Nov;14(10):935-45.
The anti-My-11 murine monoclonal antibody reported on in this work identifies a KG-1a cell surface glycoprotein with apparent molecular mass of 210,000 daltons. Peripheral blood B-lymphocytes, and a novel subset of T-lymphocytes (not coinciding with helper or cytotoxic subsets) express My-11 antigen; granulocytes, red cells, and platelets are antigen negative. In normal bone marrow, lymphoid progenitors (TdT positive) and most granulocyte-monocyte progenitors express My-11, but erythroid and multilineage progenitors are My-11 negative. Approximately half of acute leukemia blast cell specimens are My-11 positive. The My-11 antigen distinguishes between lymphohematopoietic cells on the basis of lineage, and assists in the purification of hematopoietic progenitor cells and the subclassification of leukemias and normal lymphocytes.
本研究报道的抗My-11鼠单克隆抗体识别出一种表观分子量为210,000道尔顿的KG-1a细胞表面糖蛋白。外周血B淋巴细胞以及一种新型T淋巴细胞亚群（与辅助性或细胞毒性亚群不一致）表达My-11抗原；粒细胞、红细胞和血小板为抗原阴性。在正常骨髓中，淋巴祖细胞（TdT阳性）和大多数粒细胞-单核细胞祖细胞表达My-11，但红系祖细胞和多系祖细胞为My-11阴性。大约一半的急性白血病原始细胞标本为My-11阳性。My-11抗原根据谱系区分淋巴造血细胞，并有助于纯化造血祖细胞以及对白血病和正常淋巴细胞进行亚分类。
