Colburn W A
J Pharm Sci. 1984 Mar;73(3):313-7. doi: 10.1002/jps.2600730308.
A pharmacokinetic model for calculating the pharmacokinetic parameters for a compound that is recycled in the bile is presented and tested using theoretical as well as experimental data. The results indicate that this method is stable and only slightly susceptible to sampling and recycling times. It is apparent from the present study that pharmacokinetic terms that have been used in classical situations are not directly applicable to drugs that enter the enterohepatic circulation. Effective half-life and effective clearance are used to describe the intrinsic ability of the eliminating organs to remove drug from the blood, whereas net half-life and net clearance are used to describe the irreversible elimination of the drug from the body.
提出了一种用于计算经胆汁循环的化合物药代动力学参数的药代动力学模型，并使用理论数据和实验数据进行了测试。结果表明，该方法稳定，仅对采样时间和循环时间略有敏感。从本研究中可以明显看出，经典情况下使用的药代动力学术语并不直接适用于进入肠肝循环的药物。有效半衰期和有效清除率用于描述消除器官从血液中清除药物的内在能力，而净半衰期和净清除率则用于描述药物从体内的不可逆消除。
