Tse F L, Ballard F, Skinn J
J Pharmacokinet Biopharm. 1982 Aug;10(4):455-61. doi: 10.1007/BF01065175.
A simple method of estimating the extent of biliary recycling using blood level and cumulative biliary excretion data from control and bile duct-cannulated animals is described. The method was tested in rats following an intravenous dose of [14C] temazepam. It was shown that 62% of the drug excreted in the bile of control rats was reabsorbed during each enterohepatic cycle, contributing to the secondary peak blood concentrations and a prolonged elimination half-life.
描述了一种利用对照动物和胆管插管动物的血药浓度及胆汁累积排泄数据估算胆汁再循环程度的简单方法。该方法在大鼠静脉注射[14C]替马西泮后进行了测试。结果表明，对照大鼠胆汁中排泄的药物在每个肠肝循环中有62%被重吸收，这导致了血药浓度的二次峰值和消除半衰期延长。
