进行肠肝循环的药物的效应建模。
Effect modelling for drugs undergoing enterohepatic circulation.
作者信息
Höglund P, Ohlin M
机构信息
Department of Clinical Pharmacology, University Hospital of Lund, Sweden.
出版信息
Eur J Drug Metab Pharmacokinet. 1993 Oct-Dec;18(4):333-8. doi: 10.1007/BF03190182.
PMID:8020531
Abstract
A multi-compartment pharmacokinetic model with enterohepatic circulation, was used in simulations and in a clinical trial with morphine. A hypothetical effect compartment was linked to either the central or the peripheral disposition compartment.
摘要
一个具有肠肝循环的多室药代动力学模型被用于吗啡的模拟和一项临床试验中。一个假设的效应室与中央处置室或外周处置室相连接。
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