Bertouch J V, Meffin P J, Sallustio B C, Brooks P M
Aust N Z J Med. 1983 Dec;13(6):583-6. doi: 10.1111/j.1445-5994.1983.tb02608.x.
Plasma concentrations of methylprednisolone following intra-articular injection were measured in rheumatoid arthritis and osteoarthritis patients. While substantial plasma concentrations were seen in both groups of patients there was no significant difference in the rate or extent of absorption of methylprednisolone from osteoarthritic or rheumatoid knees. This study suggests that it is the dissolution rate of the steroid formulation rather than the characteristics of the synovial membrane which determine rate and extent of systemic absorption of methylprednisolone after intra-articular injection.
对类风湿性关节炎和骨关节炎患者关节腔内注射甲泼尼龙后的血浆浓度进行了测量。虽然两组患者均出现了较高的血浆浓度，但甲泼尼龙从骨关节炎或类风湿性关节炎膝关节的吸收速率和程度并无显著差异。这项研究表明，决定关节腔内注射后甲泼尼龙全身吸收速率和程度的是类固醇制剂的溶解速率，而非滑膜的特性。
