关节内注射糖皮质激素对慢性骨关节炎患者磺胺二甲嘧啶处置的影响。
Effect of intra-articular glucocorticoids on the disposition of sulphadimidine in chronic osteoarthritis patients.
作者信息
Reeves P T, Hanrahan P, Edelman J, Ilett K F
机构信息
Department of Pharmacology, University of Western Australia, Nedlands.
出版信息
Br J Clin Pharmacol. 1988 Nov;26(5):563-8. doi: 10.1111/j.1365-2125.1988.tb05296.x.
Abstract
- The disposition of sulphadimidine (15 mg kg-1 orally) was investigated in six chronic osteoarthritis patients (four slow and two fast acetylators) prior to and 4 days following intra-articular administration of glucocorticoids. 2. The mean (+/- s.e. mean) renal clearance of sulphadimidine was increased from 0.03 +/- 0.01 to 0.07 +/- 0.02 ml min-1 kg-1 (P = 0.01) following the administration of intra-articular steroid. 3. Mean metabolic clearance and volume of distribution data were similar on the two study days. However, two of the slow acetylators showed marked increases (63% and 193%) in metabolic clearance following steroid treatment.
摘要
- 在六名慢性骨关节炎患者（四名慢乙酰化者和两名快乙酰化者）中，研究了关节内注射糖皮质激素之前及之后4天口服磺胺二甲嘧啶（15毫克/千克）的处置情况。2. 关节内注射类固醇后，磺胺二甲嘧啶的平均（±标准误）肾清除率从0.03±0.01毫升/分钟/千克增加到0.07±0.02毫升/分钟/千克（P = 0.01）。3. 两个研究日的平均代谢清除率和分布容积数据相似。然而，两名慢乙酰化者在类固醇治疗后代谢清除率显著增加（分别为63%和193%）。
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