Edelman J, Potter J M, Hackett L P
Br J Clin Pharmacol. 1986 Mar;21(3):301-7. doi: 10.1111/j.1365-2125.1986.tb05194.x.
Plasma salicylate concentrations and salicylate clearances were evaluated in 10 patients before and then 3 days after the intra-articular administration of glucocorticoid steroids. All patients were on chronic salicylate treatment, the dosage varying from 1.3-4.6 g day-1 of enteric-coated aspirin. The mean steady state plasma concentration (+/- s.e. mean) of salicylate decreased significantly after intra-articular steroid (90.9 +/- 14.8 mg l-1-64.7 +/- 8.9, P less than 0.05), whilst the mean clearance increased significantly (87.3 +/- 20.6 ml min-1-120.6 +/- 28.3, P less than 0.05). In these paired studies, the intra-articular administration of steroids lead to a significant decrease in plasma salicylate levels in patients taking enteric-coated aspirin.
在10名患者关节内注射糖皮质激素前及注射3天后，评估其血浆水杨酸浓度和水杨酸清除率。所有患者均接受慢性水杨酸治疗，肠溶阿司匹林剂量为每日1.3 - 4.6克。关节内注射类固醇后，水杨酸的平均稳态血浆浓度（±标准误）显著下降（90.9±14.8毫克/升降至64.7±8.9，P<0.05），而平均清除率显著增加（87.3±20.6毫升/分钟升至120.6±28.3，P<0.05）。在这些配对研究中，关节内注射类固醇导致服用肠溶阿司匹林的患者血浆水杨酸水平显著降低。
