Bult H, Beetens J, Rampart M, Zonnekeyn L, Herman A G
Eur J Respir Dis Suppl. 1983;126:349-56.
Almitrine bismesylate (1, 10 and 100 micrograms/ml) did not interfere with aggregation of rabbit blood platelets induced by arachidonic acid (100 micrograms/ml), ADP (10 microM) or collagen (10 micrograms/ml) in platelet rich plasma and did not augment the generation of prostacyclin by the rabbit aorta endothelium. Although almitrine bismesylate (2 mg/kg i.v.) increased the respiratory movements it did not stimulate prostacyclin biosynthesis in rabbits in vivo nor did it interfere with the ex vivo platelet aggregation induced by ADP or arachidonic acid and measured with the whole blood electronic aggregometer.
二甲磺酸烯丙苯哌嗪（1、10和100微克/毫升）不干扰富含血小板血浆中由花生四烯酸（100微克/毫升）、二磷酸腺苷（10微摩尔）或胶原蛋白（10微克/毫升）诱导的兔血小板聚集，也不增加兔主动脉内皮细胞前列环素的生成。尽管二甲磺酸烯丙苯哌嗪（静脉注射2毫克/千克）增加了呼吸运动，但它在体内并未刺激兔体内前列环素的生物合成，在用全血电子凝集仪测量时，也不干扰由二磷酸腺苷或花生四烯酸诱导的离体血小板聚集。
