早老症病例中的药物代谢

Drug metabolism in a case of progeria.

作者信息

Caldwell J, Smith R L, Davies S A

出版信息

Gerontology. 1978;24(5):373-80. doi: 10.1159/000212274.

Abstract

A case of premature ageing (progeria) in a 3-year-old Indian child is described. The conjugations of paracetamol with glucuronic acid and sulphate, of benzoic acid with glycine and of phenylacetic acid with glutamine have been investigated in this child, in view of suggestions that these reactions are impaired in old age. The results suggest that the glucuronic acid conjugation pathway may be quantitatively less important in the progeric child than in normal children and adults.

摘要

描述了一名3岁印度儿童早衰（早老症）的病例。鉴于有观点认为这些反应在老年时会受损，对该儿童体内扑热息痛与葡萄糖醛酸和硫酸盐的结合、苯甲酸与甘氨酸的结合以及苯乙酸与谷氨酰胺的结合进行了研究。结果表明，与正常儿童和成人相比，葡萄糖醛酸结合途径在患早老症的儿童中定量重要性可能较低。