Holub M, Fornůsek L, Vĕtvicka V, Chalupná J
J Leukoc Biol. 1984 Jun;35(6):605-15. doi: 10.1002/jlb.35.6.605.
After 30-min incubation, blood leukocytes of adult athymic BALB/c nude mice (nu/nu) have a distinctly higher methacrylate or yeast particle uptake than leukocytes of euthymic nu/+ or +/+ mice. This permanent enhancement is not due to humoral factors, since the percentage of phagocytosing nu/nu leukocytes increases further in nu/+ littermate's plasma. Also, chronic infection or intraperitoneal immunization causes an additional transitory increase of the percentage of phagocytosing leukocytes and numbers of particles ingested; the phagocytic performance of leukocytes of euthymic mice is raised under these conditions by a greater factor. In fetuses enhanced phagocytosis of nu/nu mice is found only in monocytes. The bulk of ingestion of methacrylate particles is mediated by Fc receptors and significantly more receptors for IgG2B, IgG1, and IgG2A are demonstrable on nu/nu neutrophils; ingestion of particles via these receptors is again higher in nu/nu neutrophils, whereas nu/nu monocytes display a higher uptake via Fc(IgG1) receptors.
经过30分钟的孵育后，成年无胸腺BALB/c裸鼠（nu/nu）的血液白细胞对甲基丙烯酸酯或酵母颗粒的摄取明显高于有胸腺的nu/+或+/+小鼠的白细胞。这种持续增强并非由于体液因素，因为在nu/+同窝小鼠的血浆中，吞噬nu/nu白细胞的百分比会进一步增加。此外，慢性感染或腹腔免疫会导致吞噬白细胞的百分比和摄取颗粒数量额外出现短暂增加；在这些条件下，有胸腺小鼠白细胞的吞噬能力提升幅度更大。在胎儿中，仅在单核细胞中发现nu/nu小鼠的吞噬作用增强。甲基丙烯酸酯颗粒的大量摄取是由Fc受体介导的，并且在nu/nu中性粒细胞上可检测到的针对IgG2B、IgG1和IgG2A的受体明显更多；通过这些受体摄取颗粒的情况在nu/nu中性粒细胞中同样更高，而nu/nu单核细胞通过Fc（IgG1）受体的摄取更高。
