Houstĕk J, Holub M
Institute of Physiology, Academy of Sciences, Czech Republic, Prague.
J Comp Physiol B. 1994;164(6):459-63. doi: 10.1007/BF00714583.
Mild cold acclimation (22 degrees C, 3 weeks) of hairless mice was shown to increase 5-fold the brown adipose tissue uncoupling protein content in immunodeficient BALB/c nu/nu mice, but by only 2.3-fold in immunocompetent BFU mice. The difference in activation of brown adipose tissue thermogenic capacity was due to a 2-fold increase in the content of brown adipose tissue in nu/nu mice only, which was paralleled by an increase in brown adipose tissue protein but not DNA content. Likewise, only in nu/nu mice the cold acclimation increased the reaction of natural killer cells in blood and peritoneal exudate with a shift from spleen to lymph nodes and increased the phagocytic index. The results indicate that the immune system may influence the defence against cold at the level of brown adipose tissue thermogenesis.
无毛小鼠轻度冷适应（22摄氏度，3周）显示，免疫缺陷的BALB/c nu/nu小鼠的棕色脂肪组织解偶联蛋白含量增加了5倍，但在免疫健全的BFU小鼠中仅增加了2.3倍。棕色脂肪组织产热能力激活的差异是由于仅nu/nu小鼠的棕色脂肪组织含量增加了2倍，同时棕色脂肪组织蛋白增加但DNA含量未增加。同样，只有nu/nu小鼠的冷适应增加了血液和腹腔渗出液中自然杀伤细胞的反应，伴随着从脾脏到淋巴结的转移，并增加了吞噬指数。结果表明，免疫系统可能在棕色脂肪组织产热水平上影响对寒冷的防御。
