Benke P J
JAMA. 1984;251(24):3267-9.
Two infants with prominent frontal bossing, hydrocephalus, microphthalmia, and small, malformed, low-set, undifferentiated ears were born to mothers who had taken isotretinoin in the first trimester of pregnancy. A Dandy-Walker malformation, microcephaly, hypertelorism, small ear canals, cleft palate, small mouth, and congenital heart disease were also observed. Isotretinoin is a potent teratogen in man; maternal ingestion early in pregnancy leads to a distinct clinical pattern of anomalies.
两名患有明显额部隆突、脑积水、小眼畸形以及耳朵小、畸形、低位且未分化的婴儿，其母亲在妊娠头三个月服用了异维甲酸。还观察到有丹迪-沃克畸形、小头畸形、眼距过宽、耳道小、腭裂、小嘴和先天性心脏病。异维甲酸在人类中是一种强效致畸剂；孕期早期母体摄入会导致一种独特的异常临床模式。
