Smith S K, Abel M H, Baird D T
Prostaglandins. 1984 Apr;27(4):591-7. doi: 10.1016/0090-6980(84)90094-7.
17 beta-estradiol and progesterone were administered to post-menopausal women to determine their effects in vivo on the capacity of human endometrium to synthesize prostaglandins (PGs) F2 alpha and E. Basal amounts of PGF2 alpha and PGE synthesized by endometrium exposed to 17 beta-estradiol and progesterone were significantly higher than the levels produced by endometrium exposed to 17 beta-estradiol alone (p less than 0.02 for both PGs). Levels found in the former endometrium were broadly comparable to levels in secretory endometrium and in the latter to amounts found in proliferative endometrium of spontaneous, ovulatory cycles.
对绝经后妇女给予17β-雌二醇和孕酮，以确定它们在体内对人子宫内膜合成前列腺素（PGs）F2α和E的能力的影响。暴露于17β-雌二醇和孕酮的子宫内膜合成的基础PGF2α和PGE量显著高于仅暴露于17β-雌二醇的子宫内膜所产生的水平（两种PGs均p<0.02）。前一种子宫内膜中的水平与分泌期子宫内膜中的水平大致相当，后一种子宫内膜中的水平与自发排卵周期的增殖期子宫内膜中的水平相当。
