Linsk J A, Franzén S
Acta Cytol. 1984 May-Jun;28(3):251-60.
The findings in aspiration cytology smears from 15 patients with metastatic hypernephroma (renal-cell carcinoma) are presented along with the criteria for cytologic classification of aspirates of primary hypernephroma. The distinctive cytopathology of needle aspirates of metastatic lesions is illustrated. A small nuclear-cytoplasmic ratio was evident in poorly differentiated cells. The cytoplasm was highly characteristic, particularly with Romanovsky stains, and was termed "opaque with or without vacuolization and granulation" to distinguish it from the so-called clear cell of histopathology, which has been denuded of its cytoplasmic content by the histologic process. Cytoplasmic vacuoles were punched out, bubbly or lacy. The partially extruded nucleus was a useful identifying feature. In 7 of the 15 cases, primary hypernephroma was indicated by the cytologic findings in the metastases. This finding may be clinically useful in diagnosing the broad spectrum of obscure paraneoplastic syndromes that may accompany this tumor.
本文介绍了15例转移性肾细胞癌（肾上腺样瘤）患者细针穿刺抽吸活检涂片的结果，以及原发性肾上腺样瘤穿刺物的细胞学分类标准。文中展示了转移性病变针吸物独特的细胞病理学特征。在分化差的细胞中，核质比小很明显。细胞质具有高度特征性，尤其是用罗曼诺夫斯基染色时，被称为“不透明，有或无空泡化和颗粒形成”，以区别于组织病理学中所谓的透明细胞，后者在组织学处理过程中其细胞质内容物已被去除。细胞质空泡呈穿孔状、气泡状或花边状。部分挤出的细胞核是一个有用的鉴别特征。在15例病例中的7例中，转移灶的细胞学检查结果提示原发性肾上腺样瘤。这一发现对于诊断可能伴随该肿瘤的各种隐匿性副肿瘤综合征可能具有临床意义。
