猪体内胃动素的释放

Motilin release in the pig.

作者信息

Modlin I M, Mitznegg P, Bloom S R

出版信息

Gut. 1978 May;19(5):399-402. doi: 10.1136/gut.19.5.399.

DOI:10.1136/gut.19.5.399

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1412103/

Abstract

Motilin is found in the upper intestine of pig and man and in man is released by acid. A similar release by acid has now been found in the pig and is associated with markedly reduced immunostainable motilin in the upper small intestine. Clamping the arteries and veins to the stimulated segment immediately reversed the rise of plasma motilin, indicating the motilin release to be an entirely local phenomenon. The apparent half life of endogenous motilin was 3.9 minutes. No release of motilin was seen after a meal and the possible physiological role of motilin thus remains speculative.

摘要

胃动素存在于猪和人的上肠道中，在人身上，它由胃酸释放。现在发现猪身上也有类似的由胃酸引发的释放情况，且这与上小肠中可免疫染色的胃动素显著减少有关。夹住刺激段的动静脉能立即逆转血浆胃动素的升高，这表明胃动素的释放完全是局部现象。内源性胃动素的表观半衰期为3.9分钟。进食后未观察到胃动素的释放，因此胃动素可能的生理作用仍属推测。

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本文引用的文献

1

Enterochromaffin cells of the mammalian small intestine as the source of motilin.哺乳动物小肠的肠嗜铬细胞作为胃动素的来源。

Virchows Arch B Cell Pathol. 1974;16(2):111-20. doi: 10.1007/BF02894069.

2

Radioimmunoassay for motilin.胃动素的放射免疫测定

Gastroenterology. 1975 May;68(5 Pt 1):1169-76.

3

Effects of 13-nle-motilin in man--inhibition of gastric evacuation and stimulation of pepsin secretion.13-去甲亮氨酸胃动素对人体的作用——抑制胃排空及刺激胃蛋白酶分泌

Scand J Gastroenterol. 1975;10(2):199-202.

4

Measurement of human plasma motilin.人血浆胃动素的测定

Scand J Gastroenterol Suppl. 1976;39:47-52.

5

Pharmacokinetics of motilin in man.胃动素在人体中的药代动力学。

Gastroenterology. 1977 Mar;72(3):413-6.

6

Release of motilin after duodenal acidification.十二指肠酸化后胃动素的释放。

Lancet. 1976 Apr 24;1(7965):888-9. doi: 10.1016/s0140-6736(76)92101-2.

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