Wiqvist I, Norström A, O'Byrne E, Wiqvist N
Acta Endocrinol (Copenh). 1984 May;106(1):127-32. doi: 10.1530/acta.0.1060127.
Cervical tissue was obtained from women undergoing legal abortion in the 7th-15th week of gestation and tissue from the lower uterine segment was excised at elective Casearean section in the 38th-40th week. The specimens were incubated with [3H]proline in the presence of relaxin or prostaglandin E2 (PGE2). Relaxin had a concentration related inhibitory effect on the radiolabelling in the 7th-9th week but failed to influence the amino acid uptake in the 10th-15th week of pregnancy. PGE2 had the inverse effect, i.e. no influence in the former group but reduced incorporation of proline in the latter group of patients. Incubation of tissue from the lower uterine segment showed a similar response as that of the early pregnant cervix. It is concluded that relaxin has a significant influence on [3H]proline incorporation by cervical and uterine tissue under in vitro experimental conditions.
宫颈组织取自妊娠7至15周接受合法堕胎的女性，子宫下段组织则在妊娠38至40周选择性剖宫产时切除。将标本在松弛素或前列腺素E2（PGE2）存在的情况下与[3H]脯氨酸一起孵育。松弛素在妊娠7至9周对放射性标记有浓度相关的抑制作用，但在妊娠10至15周未能影响氨基酸摄取。PGE2则有相反的作用，即在妊娠7至9周的组中无影响，但在妊娠10至15周的组中减少了脯氨酸的掺入。子宫下段组织的孵育显示出与早期妊娠宫颈相似的反应。结论是，在体外实验条件下，松弛素对宫颈和子宫组织中[3H]脯氨酸的掺入有显著影响。
