精英大学女性运动员血清松弛素浓度的变化趋势。
Trends in serum relaxin concentration among elite collegiate female athletes.
机构信息
Department of Orthopaedic Surgery, Stanford University, Palo Alto, CA, USA;
出版信息
Int J Womens Health. 2011 Jan 19;3:19-24. doi: 10.2147/IJWH.S14188.
PURPOSE
This study was designed to investigate the relationship between serum relaxin concentration (SRC) and menstrual history and hormonal contraceptive use among elite collegiate female athletes. Evaluation of SRC in athletes is necessary, because relaxin has been associated with increased knee joint laxity and decreased anterior cruciate ligament (ACL) strength in animal models.
METHODS
National Collegiate Athletic Association Division I female athletes participating in sports at high risk for ACL tears - basketball, field hockey, gymnastics, lacrosse, soccer, and volleyball - were invited to participate. All participants completed a questionnaire about their menstrual history and hormonal contraceptive use. Venipuncture was performed to obtain samples of serum progesterone and relaxin. Samples were obtained during the mid-luteal phase from ovulating participants, and between the actual or projected cycle days 21 to 24, from anovulatory participants. Serum concentration of relaxin and progesterone was determined by ELISA and the data were analyzed using SPSS statistical software with significance set at P = 0.05.
RESULTS
169 female athletes participated. The mean SRC among all participants was 3.08 ± 6.66 pg/mL). The mean SRC differed significantly between those participants using hormonal contraceptives (1.41 pg/mL) and those not using hormonal contraceptives (3.08 pg/mL, P = 0.002). Mean SRC was lowest among amenorrheic participants (1.02 pg/mL) and highest among oligomenorrheic participants (3.71 pg/mL) and eumenorrheic participants (3.06 pg/mL); these differences were not significant (P = 0.53). Mean serum progesterone concentration (SPC) differed significantly between those participants using hormonal contraceptives (2.80 ng/mL), and those not using hormonal contraceptives (6.99 ng/mL, P < 0.0001).
CONCLUSIONS
There is a positive correlation between serum progesterone and SRC and an attenuation of SRC with hormonal contraceptive use. Our results underscore the significant role that hormonal contraceptives can play in decreasing relaxin levels, if future investigations establish a link between relaxin levels and ligamentous injury among female athletes.
目的
本研究旨在探讨血清松弛素浓度（SRC）与月经史和激素避孕使用之间的关系，研究对象为精英大学女性运动员。对运动员的 SRC 进行评估是必要的，因为松弛素与动物模型中膝关节松弛度增加和前交叉韧带（ACL）强度降低有关。
方法
邀请参加高风险 ACL 撕裂运动的美国全国大学体育协会（NCAA）一级女性运动员参与研究，这些运动包括篮球、曲棍球、体操、曲棍球、足球和排球。所有参与者完成了一份关于月经史和激素避孕使用的问卷。通过静脉穿刺获得血清孕激素和松弛素样本。排卵参与者在黄体中期，无排卵参与者在预计或实际周期第 21 至 24 天采血。通过 ELISA 测定血清松弛素和孕激素浓度，使用 SPSS 统计软件进行数据分析，显著性水平设为 P = 0.05。
结果
169 名女性运动员参与了研究。所有参与者的平均 SRC 为 3.08 ± 6.66 pg/mL。使用激素避孕药的参与者的平均 SRC（1.41 pg/mL）与未使用激素避孕药的参与者（3.08 pg/mL）之间存在显著差异（P = 0.002）。闭经参与者的平均 SRC 最低（1.02 pg/mL），而月经稀少参与者（3.71 pg/mL）和月经正常参与者（3.06 pg/mL）的平均 SRC 最高；这些差异无统计学意义（P = 0.53）。使用激素避孕药的参与者的平均血清孕激素浓度（SPC）（2.80 ng/mL）与未使用激素避孕药的参与者（6.99 ng/mL）之间存在显著差异（P < 0.0001）。
结论
血清孕激素和 SRC 之间存在正相关，而使用激素避孕药会减弱 SRC。如果未来的研究确定女性运动员的松弛素水平与韧带损伤之间存在关联，我们的结果强调了激素避孕药在降低松弛素水平方面的重要作用。
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