Parkes J D
Acta Neurol Scand Suppl. 1983;95:27-35. doi: 10.1111/j.1600-0404.1983.tb01514.x.
As we have earlier shown, sudden extreme changes in disease severity are a characteristic feature of Parkinson's disease. These variations take two main forms, those natural to the disease and those occurring as a result of treatment. Treatment-related response variations can sometimes be attributed to the known pharmacokinetic properties of anti-parkinsonian drugs and, in particular, levodopa. These responses are time-dependent. In contrast, other types of response variation may be unpredictable in time, and are at present rarely amenable to treatment. Identification of the cause of variation is necessary for the management of parkinsonism, and particularly for the successful use of deprenyl.
正如我们之前所表明的，疾病严重程度的突然极端变化是帕金森病的一个特征。这些变化主要有两种形式，一种是疾病本身固有的，另一种是治疗导致的。与治疗相关的反应变化有时可归因于抗帕金森病药物，尤其是左旋多巴已知的药代动力学特性。这些反应是时间依赖性的。相比之下，其他类型的反应变化在时间上可能无法预测，目前很少能通过治疗来改善。确定变化的原因对于帕金森病的管理，尤其是对于成功使用司来吉兰来说是必要的。
