老年帕金森病：左旋多巴夜间给药的反应及最佳给药间隔
Parkinson's disease in the elderly: response to and optimal spacing of night time dosing with levodopa.
作者信息
Leeman A L, O'Neill C J, Nicholson P W, Deshmukh A A, Denham M J, Royston J P, Dobbs R J, Dobbs S M
机构信息
Clinical Research Centre, Northwick Park Hospital, Harrow, Middlesex.
出版信息
Br J Clin Pharmacol. 1987 Nov;24(5):637-43. doi: 10.1111/j.1365-2125.1987.tb03223.x.
Abstract
- Insomnia is an even more frequent complaint in elderly patients with Parkinson's disease than might be expected from the effect of age alone on sleep. 2. A double-blind, placebo-controlled trial in eleven patients with Parkinson's disease of mean (s.d.) age 80(5) years, showed that nocturnal dosing with levodopa produced a clinically significant improvement in sleep both as assessed subjectively and by measurement of number of spontaneous moves in bed. 3. Despite the long interval between tablet administration and morning assessment, walking time was faster on mornings following active treatment.
摘要
- 失眠在帕金森病老年患者中是比仅由年龄对睡眠的影响所预期的更为常见的主诉。2. 一项针对11名平均（标准差）年龄为80（5）岁的帕金森病患者的双盲、安慰剂对照试验表明，夜间服用左旋多巴在主观评估以及通过测量床上自发动作次数方面均产生了临床上显著的睡眠改善。3. 尽管从服药到早晨评估的间隔时间很长，但在积极治疗后的早晨，步行时间更快。
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本文引用的文献
1
The actions of amylobarbitone sodium, butobarbitone and quinalbarbitone sodium upon insomnia and nocturnal restlessness compared in psychiatric patients.在精神科患者中比较戊巴比妥钠、丁巴比妥和硫戊巴比妥钠对失眠和夜间烦躁不安的作用。
Br J Pharmacol Chemother. 1961 Feb;16(1):82-9. doi: 10.1111/j.1476-5381.1961.tb00300.x.
2
The effects of meprobamate and pentobarbitone sodium on sleep and motility during sleep: a controlled trial with psychiatric patients.眠尔通和戊巴比妥钠对睡眠及睡眠中活动的影响：一项针对精神科患者的对照试验
J Neurol Neurosurg Psychiatry. 1959 May;22(2):137-40. doi: 10.1136/jnnp.22.2.137.
3
The estimation of motility during rest or sleep.静息或睡眠期间运动能力的评估。
J Neurol Neurosurg Psychiatry. 1959 Feb;22(1):57-60. doi: 10.1136/jnnp.22.1.57.
4
Sleep disruption in the course of chronic levodopa therapy: an early feature of the levodopa psychosis.慢性左旋多巴治疗过程中的睡眠中断：左旋多巴所致精神病的早期特征。
Clin Neuropharmacol. 1982;5(2):183-94. doi: 10.1097/00002826-198205020-00003.
5
Variability in Parkinson's disease; clinical aspects, causes and treatment.帕金森病的变异性；临床特征、病因及治疗。
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6
Blink rates and disorders of movement.眨眼频率与运动障碍
Neurology. 1984 May;34(5):677-8. doi: 10.1212/wnl.34.5.677.
7
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10
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J Neurol Neurosurg Psychiatry. 1974 Apr;37(4):416-20. doi: 10.1136/jnnp.37.4.416.
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