Barr P A, Gallery E D
Aust N Z J Obstet Gynaecol. 1981 Feb;21(1):11-5. doi: 10.1111/j.1479-828x.1981.tb00116.x.
Intravenous diazoxide was given to 8 patients with severe pregnancy-associated hypertension (diastolic pressure greater than or equal to 110) in the antepartum period. Maternal hypertension was rapidly controlled in all patients; the diastolic blood pressure fell to less than or equal to 100 in all patients and to less than or equal to 85 in 7. Diazoxide had no significant effect on the basal fetal heart rate (FHR) or on the latency period or amplitude of late decelerations in the 3 patients with abnormal (positive) stress cardiotocographs (SCTG) and abnormal (unreactive) non-stress cardiotocographs (NSCTG). In the 5 patients with reactive NSCTGs, diazoxide had no significant effect on the basal FHR or on the frequency of fetal movement-induced FHR accelerations. Thus, diazoxide did not adversely affect fetal well-being in these patients with severe pregnancy-associated hypertension as assessed by cardiotocography.
对8例产前患有严重妊娠相关性高血压（舒张压大于或等于110）的患者静脉注射二氮嗪。所有患者的母体高血压均迅速得到控制；所有患者的舒张压均降至小于或等于100，7例患者的舒张压降至小于或等于85。对于3例应激胎心监护图（SCTG）异常（阳性）和无应激胎心监护图（NSCTG）异常（无反应）的患者，二氮嗪对基础胎心率（FHR）、晚期减速的潜伏期或幅度均无显著影响。在5例NSCTG有反应的患者中，二氮嗪对基础FHR或胎动引起的FHR加速频率均无显著影响。因此，通过胎心监护评估，二氮嗪对这些严重妊娠相关性高血压患者的胎儿健康没有不利影响。
