Ankerst J, Fäldt R, Nilsson P G, Flodgren P, Sjögren H O
Cancer Immunol Immunother. 1984;17(1):69-71. doi: 10.1007/BF00205501.
A 76-year-old woman with acute myelogenous leukemia with approximately 65% myeloblasts on bone marrow examination was treated daily with a combination of 4 megaU of leukocyte interferon IM and 1,000 mg cimetidine PO. During therapy there was a gradual decrease of bone marrow myeloblasts down to 9% and a normalization of peripheral white blood cells. The treatment was discontinued after 6 weeks because of increasing fatigue and anorexia. The general condition improved greatly during the following weeks and the patient entered complete remission, which has continued for 6 months so far. In the course of therapy there was a gradual appearance of antibodies showing a selective binding capacity to autochthonous leukemic cells with no tendency to increased binding to remission cells. The aim of this report is to stimulate a further evaluation of this form of therapy in additional AML patients whenever this might be justified as an alternative to conventional chemotherapy.
一名76岁患有急性髓性白血病的女性，骨髓检查显示约65%为成髓细胞，每天接受400万单位白细胞干扰素肌肉注射和1000毫克西咪替丁口服的联合治疗。治疗期间，骨髓成髓细胞逐渐减少至9%，外周血白细胞恢复正常。由于疲劳和厌食加剧，6周后停止治疗。在接下来的几周里，患者的一般状况大为改善，并进入完全缓解期，迄今为止已持续6个月。在治疗过程中，逐渐出现了对自体白血病细胞具有选择性结合能力的抗体，对缓解期细胞的结合没有增加的趋势。本报告的目的是促使在有理由将这种治疗形式作为传统化疗替代方案的情况下，对更多急性髓性白血病患者进一步评估这种治疗方法。
