Wallace J L, McCready D R, Chin B C, Track N S, Cohen M M
Clin Biochem. 1984 Jun;17(3):179-82. doi: 10.1016/s0009-9120(84)80155-1.
A technique for determination of the prostaglandin E2 biosynthetic capacity ( PGBC ) of gastric mucosa is described. The effects of food deprivation and indomethacin pretreatment on PGBC were studied. Indomethacin (1 mg/kg i.p.) significantly reduced the PGBC of fundal and antral tissue. This effect was more marked in the fundal tissue. Food deprivation for up to 22 h had no effect on fundal PGBC . In the antrum, a 12-hour fast caused a significant reduction in PGBC while a 22-hour fast had no effect. These changes in PGBC may relate to the increase in susceptibility to gastric ulceration caused by fasting or indomethacin pretreatment. This technique may be applicable to clinical studies.
本文描述了一种测定胃黏膜前列腺素E2生物合成能力（PGBC）的技术。研究了禁食和吲哚美辛预处理对PGBC的影响。吲哚美辛（1毫克/千克，腹腔注射）显著降低了胃底和胃窦组织的PGBC。这种作用在胃底组织中更为明显。禁食长达22小时对胃底PGBC没有影响。在胃窦，禁食12小时导致PGBC显著降低，而禁食22小时则没有影响。PGBC的这些变化可能与禁食或吲哚美辛预处理引起的胃溃疡易感性增加有关。该技术可能适用于临床研究。
