Tanabe M, Hasegawa E, Matsuo N, Tamai T, Satoh K, Kojima K, Sato C, Murakami T H
Eur J Nucl Med. 1984;9(5):233-6. doi: 10.1007/BF00448545.
The extent of 67Ga accumulation in the two lacrimal glands in patients with keratoconjunctivitis sicca (KCS) of Sjögren's syndrome was studied. Of the two main groups one consisted of 69 subjects without ophthalmic complaints (control group), the other consisted of 26 patients with KCS of Sjögren's syndrome. Of the 26 patients with KCS, 7 had been diagnosed as probable KCS (probable sub-group) and the other 19 had been diagnosed definite KCS (definite sub-group). About 3 mCi (111 MBq) 67Ga-citrate was injected IV into each subject and this was followed by scintigraphy at 24, 48, and 72 h after the injection of 67Ga. A positive finding in the lacrimal gland was noted in 64 of 69 subjects (92.7%) in the control group and in 7 of 7 patients (100%) with probable KCS. Three of 19 patients with definite KCS (15.7%) showed positive findings under scintigraphy. When the scintigraphic finding in the lacrimal gland is not positive in patients with suspected KCS of Sjögren's syndrome, they can then be diagnosed with little risk as definite KCS cases. Shirmer's test was performed on subjects in the probable and definite groups. There was statistical significance between the positive and equivocal or negative scintigraphic finding and Schirmer's values. These results suggest a correlation between gallium accumulation in the lacrimal gland and the tear production.
研究了干燥综合征所致角结膜干燥症（KCS）患者双侧泪腺中67镓的蓄积程度。在两个主要组中，一组由69名无眼部不适的受试者组成（对照组），另一组由26名干燥综合征所致KCS患者组成。在这26例KCS患者中，7例被诊断为可能的KCS（可能亚组），另外19例被诊断为确诊的KCS（确诊亚组）。向每位受试者静脉注射约3mCi（111MBq）的67镓柠檬酸盐，然后在注射67镓后的24、48和72小时进行闪烁扫描。对照组69名受试者中有64名（92.7%）泪腺有阳性发现，7例可能的KCS患者中有7例（100%）泪腺有阳性发现。19例确诊的KCS患者中有3例（15.7%）在闪烁扫描时有阳性发现。对于疑似干燥综合征所致KCS的患者，若其泪腺闪烁扫描结果为阴性，则可几乎无风险地诊断为确诊的KCS病例。对可能组和确诊组的受试者进行了泪液分泌试验。闪烁扫描阳性与可疑或阴性结果以及泪液分泌试验值之间存在统计学意义。这些结果提示泪腺中镓的蓄积与泪液分泌之间存在相关性。
