de Rooij J F, Nancollas G H
J Dent Res. 1984 Jun;63(6):864-7. doi: 10.1177/00220345840630061001.
Artificial white spot lesions have been prepared on bovine enamel surfaces by the controlled addition of lactate buffer containing methylhydroxydiphosphonate ions. The rates of remineralization have been measured using a constant composition method in solutions of calcium phosphate of low supersaturation. Deposition of new hydroxyapatite solid phase takes place exclusively within the white spot lesion at a rate appreciably slower than that of an acid-etched enamel surface, probably due to the presence of methylhydroxydiphosphonate located within the intact surface region of the lesion.
通过可控添加含有甲基羟基二膦酸根离子的乳酸缓冲液，在牛牙釉质表面制备了人工白斑病变。采用恒定组成法在低过饱和度的磷酸钙溶液中测量了再矿化速率。新的羟基磷灰石固相仅在白斑病变内沉积，沉积速率明显低于酸蚀牙釉质表面，这可能是由于病变完整表面区域内存在甲基羟基二膦酸根。
