Salonen J, Pelliniemi L J, Foidart J M, Risteli L, Santti R
Arch Oral Biol. 1984;29(5):363-8. doi: 10.1016/0003-9969(84)90161-4.
Type IV and V collagens, laminin and heparan sulphate proteoglycan were localized in vascular and subepithelial basement membranes. Fibronectin was distributed in a reticular pattern throughout the lamina propria under the oral epithelium. The uniform distribution of basement membrane components and type V collagen in different regions suggests a similar molecular composition for the basement membranes under functionally-different oral epithelia. The more intense reaction in the vascular than in the subepithelial basement membranes, with diluted antibodies to type IV collagen and laminin apparently reflects chemical differences in these basement membranes. Occasional discontinuities in the subepithelial basement membranes were seen in inflamed gingival sulci and in tonsillar crypts. The destruction responsible affected all basement membrane components, except fibronectin, which maintained a reticular distribution even in the deep tonsillar tissue. The immunohistochemical method is useful in demonstrating different degrees of destruction in basement membranes associated with inflammation.
IV型和V型胶原蛋白、层粘连蛋白和硫酸乙酰肝素蛋白聚糖定位于血管和上皮下基底膜。纤连蛋白以网状模式分布于口腔上皮下方的固有层中。基底膜成分和V型胶原蛋白在不同区域的均匀分布表明，功能不同的口腔上皮下方的基底膜具有相似的分子组成。用稀释的IV型胶原蛋白和层粘连蛋白抗体检测时，血管基底膜的反应比上皮下基底膜更强烈，这显然反映了这些基底膜的化学差异。在炎症牙龈沟和扁桃体隐窝中可见上皮下基底膜偶尔出现连续性中断。造成破坏的因素影响了所有基底膜成分，但纤连蛋白除外，即使在扁桃体深部组织中，纤连蛋白仍保持网状分布。免疫组织化学方法有助于证明与炎症相关的基底膜的不同程度破坏。
