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充血性心肌病尸检心脏的形态计量学分析

Morphometrical analysis of autopsy hearts of congestive cardiomyopathy.

作者信息

Tanaka M, Matsubara O, Kajita A, Hatakeyama S

出版信息

Bull Tokyo Med Dent Univ. 1983 Sep;30(3):73-94.

PMID:6589085
Abstract

To analyse the morphological changes of 25 autopsy hearts of 18 males, 7 females including 3 children with congestive cardiomyopathy (COCM), measurements of the heart weight, chamber volume, wall thickness, circumference of the valvular annulus, thickness of the valvular cusp and transverse diameter of the muscle fiber were performed. The mean onset of heart failure was 38 years of age, the mean duration 60 months, the mean age of death 43 years, the mean heart weight 513 g and the mean total chamber volume 286 ml, the mean chamber volume being 89 ml in the left ventricle (LV), 72 ml in the right ventricle (RV), 71 ml in the right atrium (RA) and 55 ml in the left atrium (LA). Various kinds of correlation among these measured parameters were analysed statistically. There was a significant correlation between the heart weight and the total chamber volume (P less than 0.05), the volume of LV and RV (p less than 0.05), the volume of RV and RA (P less than 0.01), the volume of RA and the circumference of the TV annulus (P less than 0.0001) and the volume of LA and the circumference of the MV annulus (P less than 0.001). These data were also compared according to the mode of death (arrhythmia versus heart failure) and the duration of survival (more than 5 years versus 5 years or less). No statistically significant differences between the above groups were found except for the total chamber volume.

摘要

为分析18例男性、7例女性(包括3例儿童)共25例充血性心肌病(COCM)尸检心脏的形态学变化,对心脏重量、腔室容积、壁厚、瓣膜环周长、瓣叶厚度及肌纤维横径进行了测量。心力衰竭的平均发病年龄为38岁,平均病程60个月,平均死亡年龄43岁,平均心脏重量513g,平均总腔室容积286ml,其中左心室(LV)平均腔室容积89ml,右心室(RV)72ml,右心房(RA)71ml,左心房(LA)55ml。对这些测量参数之间的各种相关性进行了统计学分析。心脏重量与总腔室容积(P<0.05)、左心室和右心室容积(P<0.05)、右心室和右心房容积(P<0.01)、右心房容积与三尖瓣环周长(P<0.0001)以及左心房容积与二尖瓣环周长(P<0.001)之间存在显著相关性。还根据死亡方式(心律失常与心力衰竭)和生存时间(超过5年与5年或以下)对这些数据进行了比较。除总腔室容积外,上述组间未发现统计学上的显著差异。

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