Dorris R L, Taylor S E
Dent Clin North Am. 1984 Jul;28(3):555-62.
An attempt has been made to discuss the adverse responses that can occur when two or more drugs are administered to the same patient. Several drugs used in dental practice or drug classes were given in tabular form as they might interact with each other or with drugs the patient might already be taking. Only those combinations of drug that are believed to produce significant adverse interactions were included. However, our knowledge of interactions of drugs is incomplete and potentially significant interactions may have been overlooked. Furthermore, new drugs with another set of actions are being marketed each year, making an attempt to simply memorize interactions a frustrating experience. Ultimately, it is the practitioners familiarity with current clinical literature and the understanding of drug actions and mechanisms by which drugs can interact that will do the most for preventing iatrogenic responses associated with multiple drug usage.
本文尝试讨论当两种或更多药物同时施用于同一患者时可能出现的不良反应。牙科实践中使用的几种药物或药物类别以表格形式列出，因为它们可能相互作用，或者与患者可能已经在服用的药物相互作用。仅纳入了那些被认为会产生显著不良相互作用的药物组合。然而，我们对药物相互作用的了解并不完整，可能忽略了潜在的显著相互作用。此外，每年都有具有另一组作用的新药上市，试图单纯记忆相互作用是一种令人沮丧的经历。最终，从业者对当前临床文献的熟悉程度以及对药物作用和药物相互作用机制的理解，对于预防与多种药物使用相关的医源性反应最为有效。
