Golomb G, Friedman M, Soskolne A, Stabholz A, Sela M N
J Dent Res. 1984 Sep;63(9):1149-53. doi: 10.1177/00220345840630091101.
The purpose of this study was to develop a sustained release device containing metronidazole for insertion within periodontal pockets and to examine the release kinetics in vitro and in vivo. Cast films of ethyl cellulose with or without polyethylene glycol, containing metronidazole, were prepared and exhibited sustained release. Release rate of metronidazole from the film was measured by means of a UV spectrophotometer, and kinetics of release in vitro was found to conform to Higuchi's diffusional model. The microbiological results proved that embedding metronidazole in ethyl cellulose film does not inhibit the biological activity. The release kinetics in vivo correlated with in vitro results, exhibiting a sustained release of metronidazole over a period of three days from 30% metronidazole with polyethylene glycol or 40% metronidazole in ethyl cellulose chloroform cast. This study demonstrates that, by embedding metronidazole in ethyl cellulose, it is possible to obtain sustained release of the drug within the periodontal pocket for three days.
本研究的目的是开发一种含甲硝唑的缓释装置，用于插入牙周袋，并研究其体外和体内释放动力学。制备了含或不含聚乙二醇的乙基纤维素铸膜，其中含有甲硝唑，并表现出缓释特性。通过紫外分光光度计测量甲硝唑从膜中的释放速率，发现体外释放动力学符合Higuchi扩散模型。微生物学结果证明，将甲硝唑包埋在乙基纤维素膜中不会抑制其生物活性。体内释放动力学与体外结果相关，在含聚乙二醇的30%甲硝唑或乙基纤维素氯仿铸膜中的40%甲硝唑中，甲硝唑在三天内持续释放。本研究表明，通过将甲硝唑包埋在乙基纤维素中，可以在牙周袋内实现药物的三天持续释放。
