Leckman J F, Caruso K A, Prusoff B A, Weissman M M, Merikangas K R, Pauls D L
Arch Gen Psychiatry. 1984 Sep;41(9):839-44. doi: 10.1001/archpsyc.1984.01790200021003.
A post hoc analysis of the relationship between depression in first-degree family members (N = 810) and specific patterns of "endogenous" symptoms in 133 probands with nonbipolar major depression revealed that concomitant appetite disturbance and excessive guilt in the depressed probands was associated with increased rates of major depression among family members. The depressed, interviewed relatives of depressed probands with appetite disturbance and excessive guilt were found to be at a 2.5 greater risk for this same subtype compared with the depressed, interviewed relatives of the remaining depressed probands. These findings suggest that this subtype of depression may "breed true" within these families.
一项对810名一级家庭成员中的抑郁症与133名非双相重度抑郁症先证者的特定“内源性”症状模式之间关系的事后分析显示，抑郁先证者中伴有食欲紊乱和过度内疚与家庭成员中重度抑郁症发病率增加有关。与其余抑郁先证者的受访抑郁亲属相比，有食欲紊乱和过度内疚的抑郁先证者的受访抑郁亲属患同一亚型抑郁症的风险高2.5倍。这些发现表明，这种抑郁症亚型可能在这些家庭中“真实遗传”。
